Granulocyte Colony-Stimulating Factor Simoa

Granulocyte-colony stimulating factor (G-CSF) is a growth factor produced by endothelial cells, macrophages, fibroblast, bone marrow stromal cells and other immune cells. The G-CSF receptor (G-CSFR) is expressed on myeloid progenitors and endothelial cells. G-CSF stimulates production and mobilization of neutrophils and regulates survival, proliferation, and differentiation of various cells of the neutrophil lineage. Importantly, G-CSF can also mobilize CD34+ stem cells from bone marrow to peripheral blood. Under normal physiological conditions, circulating levels of G-CSF are low in contrast to infection, tissue injury, inflammation, or other stress and pathological conditions. Recombinant G-CSF is used to treat neutropenia and chemotherapy-associated neutropenia.

Swiss-Prot Accession Number: P09919