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Clusterin

Clusterin

Clusterin (CLU) is the most widely accepted name for a highly conserved protein that has been identified independently by many different laboratories. Other names for CLU include: SGP2, S35-S45, apolipoprotein J, SP-40, 40, ADHC-9, gp80, GPIII, and testosterone-repressed prostate message (TRPM-2). Clusterin has been associated with the clearance of cellular debris and apoptosis. Other functions include the control of complement-mediated cell lysis, shuttling of aberrant beta-amyloid across the blood-brain barrier and lipid scavenging. The measurement of urinary or serum clusterin may play a role in the early detection of renal injury. Increased urinary levels have been observed in rat models of tubular proteinuria but not glomerular proteinuria. Increased levels have also been seen in Alzheimer?s patients.

Swiss-Prot Accession Number: P10909


Bibliography

Identification of Plexin A4 as a Novel Clusterin Receptor Links Two Alzheimers Disease Risk Genes (2016) Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD Human Molecular Genetics

medical_services Therapy Indications
Neurological Disease

The Role of Clusterin in Amyloid-B-Associated Neurodegeneration (2014) Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM JAMA Neurology

medical_services Therapy Indications
Neurological Disease

CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model (2014) Lin Y, Manning PT, Jia J, Gaut JP, Xiao Z, Capoccia BJ, Chen CC, Hiebsch RR, Upadhya G, Mohanakumar T, Frazier WA, Chapman WC Transplantation. 2014 Jun 30. [Epub ahead of print]

medical_services Therapy Indications
Kidney Function and Toxicity

Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals (2012) Song F, Poljak A, Crawford J, Kochan NA, Wen W, Cameron B, Lux O, Brodaty H, Mather K, Smythe GA, Sachdev PS PLoS One. 2012;7(6):e34078

medical_services Therapy Indications
Neurological Disease

Plasma clusterin and the risk of Alzheimer disease (2011) Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM JAMA. 305: 1322-6

medical_services Therapy Indications
Neurological Disease

Assessment of Biomarkers of Drug-induced Kidney Injury in Cynomolgus Monkeys Treated with a Triple Re-uptake Inhibitor (2011) Guha M, Heier A, Price S, Bielenstein M, Caccese RG, Heathcote DI, Simpson TR, Stong DB, Bodes E Toxicol Sci. 2011 Jan 22. [Epub ahead of print]

medical_services Therapy Indications
Kidney Function and Toxicity

Urinary clusterin, cystatin C, ?2-microglobulin and total protein as markers to detect drug-induced kidney injury (2010) Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G Nat Biotechnol 28: 463-469.

medical_services Therapy Indications
Kidney Function and Toxicity